Publications

C. A. Curcio, Messinger, J. D., Mitra, A. M., Sloan, K. R., McGwin, G., Jr, Spaide, R., 2011. Human chorioretinal layer thicknesses measured using macula-wide high resolution histological sections. Invest Ophthalmol Vis Sci 52, 3943-3954 PMID 21421869. PMID 21421869

C. A. Curcio, Messinger, J. D., Sloan, K. R., McGwin, G., Jr, Medeiros, N. E., Spaide, R. F., 2013. Subretinal drusenoid deposits in non-neovascular age-related macular degeneration: morphology, prevalence, topography, and biogenesis model. Retina 33, 265-276. PMID 23266879.

Ooto, S., Vongkulsiri, S., Sato, T., Suzuki, M., C. A. Curcio, Spaide, R. F., 2014. Outer retinal corrugations in age-related macular degeneration. JAMA Ophthalmol 132, 806-813. PMID 24801396

Schaal, K. B., Freund, K. B., Litts, K. M., Zhang, Y., Messinger, J. D., C. A. Curcio, 2015. Outer retinal tubulation in age-related macular degeneration: optical coherence tomographic findings correspond with histology. Retina 1/31/15 online PMID 25635579

Litts, K. M., Messinger, J. D., Zhang, Y., Freund, K. B., C. A. Curcio, 2015. Inner segment remodeling and mitochondrial translocation in degenerating cones of age-related macular degeneration, including outer retinal tubulation. Invest Ophthalmol Vis Sci 56, 2243–2253. PMID 25758815

Pang, C., Messinger, J. D., Zanzottera, E. C., Freund, K. B., C. A. Curcio, 2015. The Onion Sign in neovascular age-related macular degeneration represents cholesterol crystals. Ophthalmology 122, 2316-2326. PMID 26298717

Schaal, K. B., Freund, K. B., Litts, K. M., Zhang, Y., Messinger, J. D., C. A. Curcio, 2015. Outer retinal tubulation in advanced age-related macular degeneration: optical coherence tomographic findings correspond to histology. Retina 35, 1339-1350. PMID 25635579

Zanzottera, E. C., Messinger, J. D., Ach, T., Smith, R. T., C. A. Curcio, 2015. Subducted and Melanotic cells in advanced age-related macular degeneration are derived from retinal pigment epithelium. Invest Ophthalmol Vis Sci 56, 3269-3278. PMID 26024109

Zanzottera, E. C., Messinger, J. D., Ach, T., Smith, R. T., Freund, K. B., C. A. Curcio, 2015. The Project MACULA retinal pigment epithelium grading system for histology and optical coherence tomography in age-related macular degeneration. Invest Ophthalmol Vis Sci 56, 3253-3268. PMID 25813989

Chen, K. C., Jung, J. J., C. A. Curcio, Balaratnasingam, C., Gallego-Pinazo, R., Dolz-Marco, R., Freund, K. B., Yannuzzi, L. A., 2016. Intraretinal hyperreflective foci in acquired vitelliform lesions of the macula: clinical and histologic study. Am J Ophthalmol 164, 89-98. PMID 26868959

C. A. Curcio, Ach, T., 2016. Macrophages or retinal pigment epithelium expressing macrophage markers in age-related macular degeneration? Comment on Lad et al. 2015. Graefes Arch Clin Exp Ophthalmol 254, 1237-1238. PMID 26897741

Litts, K. M., Ach, T., Hammack, K. M., Sloan, K. R., Zhang, Y., Freund, K. B., C. A. Curcio, 2016. Quantitative analysis of outer retinal tubulation in age-related macular degeneration from spectral-domain optical coherence tomography and histology. Invest Ophthalmol Vis Sci 57, 2647-2656. PMID 27177321

Sevilla, M. B., McGwin, G., Jr., Lad, E. M., Clark, M., Yuan, E. L., Farsiu, S., C. A. Curcio, Owsley, C., Toth, C. A., 2016. Relating retinal morphology and function in aging and early to intermediate age-related macular degeneration subjects. Am J Ophthalmol 165, 65-77. PMID 26940163

Zanzottera, E. C., Ach, T., Huisingh, C., Messinger, J. D., Freund, K. B., C. A. Curcio, 2016. Visualizing retinal pigment epithelium phenotypes in the transition to atrophy in neovascular age-related macular degeneration. Retina 36 Suppl 1, S26-S39. PMID 27685678

Zanzottera, E. C., Ach, T., Huisingh, C., Messinger, J. D., Spaide, R. F., C. A. Curcio, 2016. Visualizing retinal pigment epithelium phenotypes in the transition to geographic atrophy in age-related macular degeneration. Retina 36 Suppl 1, S12-S25. PMID 27658287

Balaratnasingam, C., Messinger, J. D., Sloan, K. R., Yannuzzi, L. A., Freund, K. B., C. A. Curcio, 2017. Histologic and optical coherence tomographic correlations in drusenoid pigment epithelium detachment in age-related macular degeneration. Ophthalmology 124, 644- 656. PMID 28153442

C. A. Curcio, Zanzottera, E. C., Ach, T., Balaratnasingam, C., Freund, K. B., 2017. Activated retinal pigment epithelium, an optical coherence tomography biomarker for progression in age-related macular degeneration. Invest Ophthalmol Vis Sci 58, BIO211-BIO226. PMID 28785769

Govetto, A., Bhavsar, K. V., Virgili, G., Gerber, M., Freund, K. B., C. A. Curcio, Burgoyne, C. F., Hubschman, J.-P., Sarraf, D., 2017. Tractional abnormalities of the central foveal bouquet in epiretinal membranes: clinical spectrum and pathophysiological perspectives. Am J Ophthalmol 184, 167-180. PMID 29106913

Pilgrim, M. G., Lengyel, I., Lanzirotti, A., Newville, M., Fearn, S., Emri, E., Knowles, J. C., Messinger, J. D., Read, R. W., Guidry, C., C. A. Curcio, 2017. Sub-retinal pigment epithelial deposition of drusen components including hydroxyapatite in a primary cell culture model. Invest Ophthalmol Vis Sci 58, 708–719. PMID 28146236

Tan, A. C. S., Astroz, P., Dansingani, K. K., Slakter, J. S., Yannuzzi, L. A., C. A. Curcio, Freund, K. B., 2017. The plateau, an optical coherence tomographic signature of geographic atrophy: evolution, multimodal imaging, and candidate histology. Invest Ophthalmol Vis Sci 58, 2349–2358. PMID 28437524

Dolz-Marco, R., Glover, J. P., Litts, K. M., Messinger, J. D., Zhang, Y., Cozzi, M., Pelligrini, M., Gal-Or, O., Freund, K. B., Staurenghi, G., C. A. Curcio, 2018. Choroidal and sub-retinal pigment epithelium caverns: multimodal imaging and correspondence with Friedman lipid globules. Ophthalmology 125, 1287-1301. PMID 29625839

Li, M., Huisingh, C., Messinger, J. D., Dolz-Marco, R., Ferrara, D., Freund, K. B., C. A. Curcio, 2018. Histology of geographic atrophy secondary to age-related macular degeneration: a multilayer approach. Retina 38, 1937-1953. PMID 29746415

Tan, A. C., Pilgrim, M., Fearn, S., Bertazzo, S., Tsolaki, E., Morrell, A., Li, M., Messinger, J. D., Dolz-Marco, R., Nittala, M. G., Lei, J., Sadda, S. R., Lengyel, I., Freund, K. B., C. A. Curcio, 2018. Calcified nodules in retinal drusen are associated with disease progression with age-related macular degeneration. Sci Transl Med 10, 466-477. PMID 30404862

Chen, L., Messinger, J. D., Zhang, Y., Spaide, R. F., Freund, K. B., C. A. Curcio, 2019. Subretinal drusenoid deposit in age-related macular degeneration: histologic insights into initiation, progression to atrophy, and imaging. Retina 10/11/19 online. PMID 31599795

Forthcoming
Chen, L., Messinger, J. D., Swain, T. A., McGwin, G., Jr, Sloan, K. R., Spaide, R. F., Freund, K. B., Duncan, J. L., C. A. Curcio Basal linear deposit in age-related macular degeneration: impact, clinicopathologic correlation, and relation to subretinal drusenoid deposit. Retina in preparation. PMID n.a.

Echols, B. S., Clark, M. E., Swain, T. A., Chen, L., Zhang, Y., McGwin Jr, G., Singireddy, R., Mays, C., Kilpatrick, D., Crosson, J. N., Owsley, C., C. A. Curcio Hyperreflective foci and specks are associated with delayed rod-mediated dark adaptation in non-neovascular age-related macular degeneration Ophthalmology Retina 5/15/19 in preparation. PMID n.a.

Sura, A. A., Chen, L., Swain, T. A., McGwin Jr, G., C. A. Curcio Measuring the contributions of basal laminar deposit and Bruch’s membrane in age-related macular degeneration. Invest Ophthalmol Vis Sci 6/20/19 in preparation. PMID n.a.a