Publications

Curcio, C. A., Messinger, J. D., Mitra, A. M., Sloan, K. R., McGwin, G., Jr, Spaide, R., 2011. Human chorioretinal layer thicknesses measured using macula-wide high resolution histological sections. Invest Ophthalmol Vis Sci 52, 3943-3954 PMID 21421869. PMID 21421869

Curcio, C. A., Messinger, J. D., Sloan, K. R., McGwin, G., Jr, Medeiros, N. E., Spaide, R. F., 2013. Subretinal drusenoid deposits in non-neovascular age-related macular degeneration: morphology, prevalence, topography, and biogenesis model. Retina 33, 265-276. PMID 23266879.

Ooto, S., Vongkulsiri, S., Sato, T., Suzuki, M., Curcio, C. A., Spaide, R. F., 2014. Outer retinal corrugations in age-related macular degeneration. JAMA Ophthalmol 132, 806-813. PMID 24801396

Schaal, K. B., Freund, K. B., Litts, K. M., Zhang, Y., Messinger, J. D., Curcio, C. A., 2015. Outer retinal tubulation in age-related macular degeneration: optical coherence tomographic findings correspond with histology. Retina 1/31/15 online PMID 25635579

Litts, K. M., Messinger, J. D., Zhang, Y., Freund, K. B., Curcio, C. A., 2015. Inner segment remodeling and mitochondrial translocation in degenerating cones of age-related macular degeneration, including outer retinal tubulation. Invest Ophthalmol Vis Sci 56, 2243–2253. PMID 25758815

Pang, C., Messinger, J. D., Zanzottera, E. C., Freund, K. B., Curcio, C. A., 2015. The Onion Sign in neovascular age-related macular degeneration represents cholesterol crystals. Ophthalmology 122, 2316-2326. PMID 26298717


Schaal, K. B., Freund, K. B., Litts, K. M., Zhang, Y., Messinger, J. D., Curcio, C. A., 2015. Outer retinal tubulation in advanced age-related macular degeneration: optical coherence tomographic findings correspond to histology. Retina 35, 1339-1350. PMID 25635579


Zanzottera, E. C., Messinger, J. D., Ach, T., Smith, R. T., Curcio, C. A., 2015. Subducted and Melanotic cells in advanced age-related macular degeneration are derived from retinal pigment epithelium. Invest Ophthalmol Vis Sci 56, 3269-3278. PMID 26024109


Zanzottera, E. C., Messinger, J. D., Ach, T., Smith, R. T., Freund, K. B., Curcio, C. A., 2015. The Project MACULA retinal pigment epithelium grading system for histology and optical coherence tomography in age-related macular degeneration. Invest Ophthalmol Vis Sci 56, 3253-3268. PMID 25813989


Chen, K. C., Jung, J. J., Curcio, C. A., Balaratnasingam, C., Gallego-Pinazo, R., Dolz-Marco, R., Freund, K. B., Yannuzzi, L. A., 2016. Intraretinal hyperreflective foci in acquired vitelliform lesions of the macula: clinical and histologic study. Am J Ophthalmol 164, 89-98. PMID 26868959


Curcio, C. A., Ach, T., 2016. Macrophages or retinal pigment epithelium expressing macrophage markers in age-related macular degeneration? Comment on Lad et al. 2015. Graefes Arch Clin Exp Ophthalmol 254, 1237-1238. PMID 26897741


Litts, K. M., Ach, T., Hammack, K. M., Sloan, K. R., Zhang, Y., Freund, K. B., Curcio, C. A., 2016. Quantitative analysis of outer retinal tubulation in age-related macular degeneration from spectral-domain optical coherence tomography and histology. Invest Ophthalmol Vis Sci 57, 2647-2656. PMID 27177321


Sevilla, M. B., McGwin, G., Jr., Lad, E. M., Clark, M., Yuan, E. L., Farsiu, S., Curcio, C. A., Owsley, C., Toth, C. A., 2016. Relating retinal morphology and function in aging and early to intermediate age-related macular degeneration subjects. Am J Ophthalmol 165, 65-77. PMID 26940163


Zanzottera, E. C., Ach, T., Huisingh, C., Messinger, J. D., Freund, K. B., Curcio, C. A., 2016. Visualizing retinal pigment epithelium phenotypes in the transition to atrophy in neovascular age-related macular degeneration. Retina 36 Suppl 1, S26-S39. PMID 27685678


Zanzottera, E. C., Ach, T., Huisingh, C., Messinger, J. D., Spaide, R. F., Curcio, C. A., 2016. Visualizing retinal pigment epithelium phenotypes in the transition to geographic atrophy in age-related macular degeneration. Retina 36 Suppl 1, S12-S25. PMID 27658287


Balaratnasingam, C., Messinger, J. D., Sloan, K. R., Yannuzzi, L. A., Freund, K. B., Curcio, C. A., 2017. Histologic and optical coherence tomographic correlations in drusenoid pigment epithelium detachment in age-related macular degeneration. Ophthalmology 124, 644- 656. PMID 28153442


Curcio, C. A., Zanzottera, E. C., Ach, T., Balaratnasingam, C., Freund, K. B., 2017. Activated retinal pigment epithelium, an optical coherence tomography biomarker for progression in age-related macular degeneration. Invest Ophthalmol Vis Sci 58, BIO211-BIO226. PMID 28785769


Govetto, A., Bhavsar, K. V., Virgili, G., Gerber, M., Freund, K. B., Curcio, C. A., Burgoyne, C. F., Hubschman, J.-P., Sarraf, D., 2017. Tractional abnormalities of the central foveal bouquet in epiretinal membranes: clinical spectrum and pathophysiological perspectives. Am J Ophthalmol 184, 167-180. PMID 29106913


Pilgrim, M. G., Lengyel, I., Lanzirotti, A., Newville, M., Fearn, S., Emri, E., Knowles, J. C., Messinger, J. D., Read, R. W., Guidry, C., Curcio, C. A., 2017. Sub-retinal pigment epithelial deposition of drusen components including hydroxyapatite in a primary cell culture model. Invest Ophthalmol Vis Sci 58, 708–719. PMID 28146236


Tan, A. C. S., Astroz, P., Dansingani, K. K., Slakter, J. S., Yannuzzi, L. A., Curcio, C. A., Freund, K. B., 2017. The plateau, an optical coherence tomographic signature of geographic atrophy: evolution, multimodal imaging, and candidate histology. Invest Ophthalmol Vis Sci 58, 2349–2358. PMID 28437524


Dolz-Marco, R., Glover, J. P., Litts, K. M., Messinger, J. D., Zhang, Y., Cozzi, M., Pelligrini, M., Gal-Or, O., Freund, K. B., Staurenghi, G., Curcio, C. A., 2018. Choroidal and sub-retinal pigment epithelium caverns: multimodal imaging and correspondence with Friedman lipid globules. Ophthalmology 125, 1287-1301. PMID 29625839


Li, M., Huisingh, C., Messinger, J. D., Dolz-Marco, R., Ferrara, D., Freund, K. B., Curcio, C. A., 2018. Histology of geographic atrophy secondary to age-related macular degeneration: a multilayer approach. Retina 38, 1937-1953. PMID 29746415


Tan, A. C., Pilgrim, M., Fearn, S., Bertazzo, S., Tsolaki, E., Morrell, A., Li, M., Messinger, J. D., Dolz-Marco, R., Nittala, M. G., Lei, J., Sadda, S. R., Lengyel, I., Freund, K. B., Curcio, C. A., 2018. Calcified nodules in retinal drusen are associated with disease progression with age-related macular degeneration. Sci Transl Med 10, 466-477. PMID 30404862


Chen, L., Messinger, J. D., Zhang, Y., Spaide, R. F., Freund, K. B., Curcio, C. A., 2019. Subretinal drusenoid deposit in age-related macular degeneration: histologic insights into initiation, progression to atrophy, and imaging. Retina 10/11/19 online. PMID 31599795

Forthcoming
Chen, L., Messinger, J. D., Swain, T. A., McGwin, G., Jr, Sloan, K. R., Spaide, R. F., Freund, K. B., Duncan, J. L., Curcio, C. A. Basal linear deposit in age-related macular degeneration: impact, clinicopathologic correlation, and relation to subretinal drusenoid deposit. Retina in preparation. PMID n.a.

Echols, B. S., Clark, M. E., Swain, T. A., Chen, L., Zhang, Y., McGwin Jr, G., Singireddy, R., Mays, C., Kilpatrick, D., Crosson, J. N., Owsley, C., Curcio, C. A. Hyperreflective foci and specks are associated with delayed rod-mediated dark adaptation in non-neovascular age-related macular degeneration Ophthalmology Retina 5/15/19 in preparation. PMID n.a.

Sura, A. A., Chen, L., Swain, T. A., McGwin Jr, G., Curcio, C. A. Measuring the contributions of basal laminar deposit and Bruch’s membrane in age-related macular degeneration. Invest Ophthalmol Vis Sci 6/20/19 in preparation. PMID n.a.a